Felypressin increases blood pressure during dental procedures in hypertensive patients

Arq Bras Cardiol. 2012 Aug;99(2):724-31. doi: 10.1590/s0066-782x2012005000062. Epub 2012 Jun 28.
[Article in English, Portuguese]


Background: Felypressin has been added to local anesthetic to increase the length of the anesthetic effect and reduce toxicity during dental procedures. However, the effect on blood pressure remains uncertain, and this may be highly relevant in the dental treatment of hypertensive patients.

Objective: To investigate the effect of felypressin on blood pressure in hypertensive patients with controlled BP.

Methods: 71 subjects with these characteristics and in need of periodontal treatment were studied. After 10 minutes of rest, local anesthesia (prilocaine) was infiltrated with and without addition of felypressin. Then, a deep subgingival scaling was performed. Blood pressure was measured by an automated oscillometric device (DIXTAL DX2010). Ten minutes after the administration of the anesthetic, peak anesthetic action was recorded. The State-Trait Anxiety Inventory (STAI) was used to assess the patients' trait anxiety.

Results: Systolic blood pressure increased after anesthesia, regardless of association with felypressin, throughout the dental procedure (p<0.05) and this response can be explained, at least in part, by the trait anxiety levels of the subjects. However, a further increase in diastolic blood pressure was observed when prilocaine was associated with felypressin (p<0.05), but this response did not change with trait anxiety levels.

Conclusion: Felypressin increased the diastolic blood pressure of hypertensive patients with controlled blood pressure. Patients with high trait anxiety presented increases in systolic blood pressure upon some procedures, suggesting that an increase in blood pressure might also be related to fear or anxiety.

MeSH terms

  • Adult
  • Analysis of Variance
  • Anesthesia, Dental / adverse effects*
  • Anxiety / psychology
  • Blood Pressure / drug effects*
  • Felypressin / adverse effects*
  • Female
  • Humans
  • Hypertension / chemically induced*
  • Hypertension / psychology
  • Male
  • Middle Aged
  • Periodontal Diseases / therapy
  • Statistics, Nonparametric
  • Time Factors
  • Vasoconstrictor Agents / adverse effects*


  • Vasoconstrictor Agents
  • Felypressin