Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma

World J Gastroenterol. 2012 Jun 21;18(23):2995-3003. doi: 10.3748/wjg.v18.i23.2995.


Aim: To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).

Methods: A retrospective study admitted three hundred fifty-four patients with HBV-related HCC. The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining. Prognostic factors influencing survival, metastasis and recurrence were assessed.

Results: Intratumoral MACC1 level was found to be associated with HCC disease progression. Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression, as compared to those with low intratumoral MACC1 levels (TFS: 34 mo vs 48.0 mo, P < 0.001; OS: 40 mo vs 48 mo, P < 0.01). Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P < 0.001).

Conclusion: High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC. MACC1 may serve as a prognostic biomarker for postoperative HCC.

Keywords: Hepatocellular carcinoma; Metastasis-as-sociated in colon cancer 1; Prognostic factor; Recurrence; c-Met.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / metabolism*
  • Carcinoma, Hepatocellular / metabolism*
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / virology
  • Disease Progression
  • Female
  • Hepatitis B, Chronic / complications
  • Humans
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / pathology
  • Liver Neoplasms / virology
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / metabolism*
  • Proto-Oncogene Proteins c-met / metabolism
  • Retrospective Studies
  • Survival Analysis
  • Trans-Activators
  • Transcription Factors / metabolism*
  • Young Adult


  • Biomarkers, Tumor
  • MACC1 protein, human
  • Trans-Activators
  • Transcription Factors
  • Proto-Oncogene Proteins c-met