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. 2012 May 1;1(3):375-376.
doi: 10.4161/onci.18964.

Egfl7 promotes tumor escape from immunity

Sébastien Pinte  1 , Fabrice Soncin  1
Affiliations

Egfl7 promotes tumor escape from immunity

Sébastien Pinte et al. Oncoimmunology. .

Abstract

Egfl7 is an endothelial-specific gene which expression is deregulated in human cancers. We showed that Egfl7 promotes tumor escape from immunity by downregulating the expression of leukocyte adhesion molecules in endothelial cells, thus repressing immune cell extravasation into tumors.

Keywords: adhesion molecules; angiogenesis; endothelium; escape from immunity; extravasation.

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Figures

None
Figure 1. Control tumors (top) show a large infiltration of CD3ε+ T-lymphocytes (brown) and express high levels of ICAM-1 (green) and VCAM-1 (red). Tumors expressing Egfl7 (bottom) have a reduced infiltration of T-lymphocytes which mainly remain in the blood circulation (arrows), blood vessels express much less ICAM-1 and VCAM-1 (inserts).
See this image and copyright information in PMC

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