Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

Oncoimmunology. 2012 May 1;1(3):393-395. doi: 10.4161/onci.19070.


The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATP-degrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.