Impact of food matrix on isoflavone metabolism and cardiovascular biomarkers in adults with hypercholesterolemia

Food Funct. 2012 Oct;3(10):1051-8. doi: 10.1039/c2fo10284f. Epub 2012 Jun 27.

Abstract

The role of food matrix and gender on soy isoflavone metabolism and biomarkers of activity were examined in twenty free-living adults (34.7 ± 11.5 years old) with hypercholesterolemia (221.9 ± 18.7mg dL(-1)). In a randomized crossover design study, participants consumed soy bread (3 wk) or a soy beverage (3 wk) containing 20 g soy protein with 99 and 93 mg isoflavones aglycone equivalents per day, respectively. During soy bread intervention, women had significantly greater microbial metabolite excretion (P = 0.05) of isoflavonoids than men. In men, isoflavone metabolite excretion was not discernibly different between the two matrices. Significant reductions (P≤ 0.05) in triglycerides (24.8%), LDL cholesterol (6.0%), apolipoprotein A-I (12.3%), and lipid oxidative stress capacity (25.5%), were observed after soy food intervention. Our findings suggest that the food matrix significantly impacts soy isoflavone metabolism, particularly microbial metabolites in women.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Apolipoprotein A-I / blood
  • Biomarkers / blood*
  • Cholesterol, LDL / blood
  • Cross-Over Studies
  • Diet
  • Female
  • Genistein / analysis
  • Genistein / metabolism
  • Humans
  • Hypercholesterolemia / metabolism*
  • Hypercholesterolemia / physiopathology
  • Isoflavones / administration & dosage*
  • Isoflavones / analysis
  • Isoflavones / metabolism
  • Isoflavones / pharmacokinetics
  • Isoflavones / urine
  • Male
  • Middle Aged
  • Oxidative Stress
  • Soy Foods / analysis
  • Soybean Proteins / analysis
  • Soybean Proteins / metabolism
  • Triglycerides / blood
  • Young Adult

Substances

  • Apolipoprotein A-I
  • Biomarkers
  • Cholesterol, LDL
  • Isoflavones
  • Soybean Proteins
  • Triglycerides
  • daidzein
  • Genistein