Posttranslational modifications in connexins and pannexins

J Membr Biol. 2012 Jun;245(5-6):319-32. doi: 10.1007/s00232-012-9453-3. Epub 2012 Jun 28.


Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function. In this review, we assess the evidence for ubiquitination, glycosylation, phosphorylation, S-nitrosylation as well as other modifications in connexins and pannexin proteins. Based on the literature, we find that posttranslational modifications are an important component of connexin and pannexin regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Connexins / metabolism*
  • Glycosylation
  • Humans
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Ubiquitination


  • Connexins