Get on the exosome bus with ALIX

Nat Cell Biol. 2012 Jun 29;14(7):654-5. doi: 10.1038/ncb2530.

Abstract

Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcium-Binding Proteins / metabolism*
  • Cell Cycle Proteins / metabolism*
  • Endosomal Sorting Complexes Required for Transport / metabolism*
  • Exosomes / metabolism*
  • Humans
  • Signal Transduction*
  • Syndecans / metabolism*
  • Syntenins / metabolism*

Substances

  • Calcium-Binding Proteins
  • Cell Cycle Proteins
  • Endosomal Sorting Complexes Required for Transport
  • PDCD6IP protein, human
  • Pdcd6ip protein, mouse
  • Syndecans
  • Syntenins