Hypersensitivity reactions to proton pump inhibitors

Curr Opin Allergy Clin Immunol. 2012 Aug;12(4):348-53. doi: 10.1097/ACI.0b013e328355b8d3.


Purpose of review: Proton pump inhibitors (PPI) are one of most frequently prescribed drugs in the world. The purpose of this review is to describe the hypersensitivity reactions to PPI.

Recent findings: Hypersensitivity reactions to PPI vary from mild symptoms to life-threatening disorders. Cases of urticaria, angioedema, anaphylaxis, cytopenia, vasculitis, acute allergic interstitial nephritis, occupational contact dermatitis, photoallergic dermatitis, maculopapular eruption, erythroderma, Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, Stevens-Johnson syndrome/toxic epidermal necrolysis, and other autoimmune reactions (including cutaneous lupus erythematosus) have been described.

Summary: A high level of clinical suspicion is critical in the diagnosis of PPI-induced hypersensitivity reactions. Physicians should be aware of the possible hypersensitivity reactions due to PPI and routine/empirical prescription for PPI should only be used when clinically indicated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Anaphylaxis / chemically induced
  • Anaphylaxis / diagnosis
  • Angioedema / chemically induced
  • Angioedema / diagnosis
  • Dermatitis, Exfoliative / chemically induced
  • Dermatitis, Exfoliative / diagnosis
  • Dermatitis, Photoallergic / diagnosis
  • Drug Hypersensitivity / diagnosis*
  • Eosinophilia / chemically induced
  • Eosinophilia / diagnosis
  • Female
  • Humans
  • Lupus Erythematosus, Cutaneous / chemically induced
  • Lupus Erythematosus, Cutaneous / diagnosis
  • Male
  • Nephritis, Interstitial / chemically induced
  • Nephritis, Interstitial / diagnosis
  • Proton Pump Inhibitors / adverse effects*
  • Proton Pump Inhibitors / pharmacology
  • Stevens-Johnson Syndrome / chemically induced
  • Stevens-Johnson Syndrome / diagnosis


  • Proton Pump Inhibitors