Myelin basic protein synthesis is regulated by small non-coding RNA 715

EMBO Rep. 2012 Sep;13(9):827-34. doi: 10.1038/embor.2012.97. Epub 2012 Jun 29.


Oligodendroglial Myelin Basic Protein (MBP) synthesis is essential for myelin formation in the central nervous system. During oligodendrocyte differentiation, MBP mRNA is kept in a translationally silenced state while intracellularly transported, until neuron-derived signals initiate localized MBP translation. Here we identify the small non-coding RNA 715 (sncRNA715) as an inhibitor of MBP translation. SncRNA715 localizes to cytoplasmic granular structures and associates with MBP mRNA transport granule components. We also detect increased levels of sncRNA715 in demyelinated chronic human multiple sclerosis lesions, which contain MBP mRNA but lack MBP protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism
  • Brain / pathology
  • Cell Line
  • Cytoplasmic Granules / metabolism
  • Gene Expression Regulation*
  • Humans
  • Mice
  • Multiple Sclerosis / metabolism
  • Multiple Sclerosis / pathology
  • Myelin Basic Protein / biosynthesis*
  • Myelin Basic Protein / genetics
  • Myelin Basic Protein / metabolism
  • Myelin Sheath / metabolism
  • Oligodendroglia / metabolism
  • Protein Biosynthesis
  • RNA, Messenger / biosynthesis
  • RNA, Small Untranslated / metabolism*
  • Rats


  • Myelin Basic Protein
  • RNA, Messenger
  • RNA, Small Untranslated