Anatomic evidence of spontaneous intrauterine closure of a ventricular septal defect

Pediatr Cardiol. 1990 Oct;11(4):208-10. doi: 10.1007/BF02238368.


An infant, born to a mother on carbamazepine monotherapy, had a complex cardiac anomaly, consisting of double-outlet right ventricle (DORV), right-sided aorta, pulmonary artery hypoplasia, left ventricular endocardial fibroelastosis, and anatomic evidence of a spontaneously closed muscular ventricular septal defect (VSD). The last finding is one which, to the best of our knowledge, has never been illustrated before.

Publication types

  • Case Reports

MeSH terms

  • Asphyxia Neonatorum / pathology*
  • Female
  • Fetal Membranes, Premature Rupture / pathology
  • Heart Septal Defects, Ventricular / embryology*
  • Heart Septal Defects, Ventricular / pathology
  • Heart Septum / embryology
  • Heart Septum / pathology
  • Heart Ventricles / embryology
  • Heart Ventricles / pathology
  • Humans
  • Hyaline Membrane Disease / pathology
  • Infant, Newborn
  • Pregnancy