Interaction between tylosin and bentonite clay from a pharmacokinetic perspective

Vet J. 2012 Dec;194(3):437-9. doi: 10.1016/j.tvjl.2012.05.016. Epub 2012 Jun 28.


The interaction between bentonite and tylosin was investigated in broiler chickens, based on pharmacokinetic characteristics obtained in vivo. Simultaneous oral administration of bentonite and tylosin significantly lowered plasma levels of tylosin and reduced the area under the plasma concentration-time curve (AUC(0-inf)), maximal plasma concentration (C(max)), time to maximal plasma concentration (T(max)) and relative oral bioavailability. The results prove unambiguously the binding of tylosin by bentonite. Simultaneous administration of tylosin (in the drinking water or feed) and bentonite (mixed in the feed as a mycotoxin binder) should therefore be avoided.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Aluminum Silicates / pharmacokinetics*
  • Animal Feed / analysis
  • Animals
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / pharmacokinetics*
  • Area Under Curve
  • Bentonite / pharmacokinetics*
  • Biological Availability
  • Chickens / physiology*
  • Chromatography, Liquid / veterinary
  • Clay
  • Drug Combinations
  • Drug Interactions
  • Tandem Mass Spectrometry / veterinary
  • Tylosin / blood
  • Tylosin / pharmacokinetics*


  • Aluminum Silicates
  • Anti-Bacterial Agents
  • Drug Combinations
  • Bentonite
  • Clay
  • Tylosin