Scaffold protein Homer 1: implications for neurological diseases

Neurochem Int. 2012 Oct;61(5):731-8. doi: 10.1016/j.neuint.2012.06.014. Epub 2012 Jun 27.


Homer proteins are commonly known as scaffold proteins at postsynaptic density. Homer 1 is a widely studied member of the Homer protein family, comprising both synaptic structure and mediating postsynaptic signaling transduction. Both an immediate-early gene encoding a Homer 1 variant and a constitutively expressed Homer 1 variant regulate receptor clustering and trafficking, intracellular calcium homeostasis, and intracellular molecule complex formation. Substantial preclinical investigations have implicated that each of these Homer 1 variants are associated with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, drug-induced addiction, and traumatic brain injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Homer Scaffolding Proteins
  • Humans
  • Nervous System Diseases / etiology*
  • Nervous System Diseases / genetics
  • Nervous System Diseases / metabolism*
  • Nuclear Matrix-Associated Proteins / genetics
  • Nuclear Matrix-Associated Proteins / physiology


  • Carrier Proteins
  • Homer Scaffolding Proteins
  • Nuclear Matrix-Associated Proteins