Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

Nat Genet. 2012 Jul 1;44(8):890-4. doi: 10.1038/ng.2337.

Abstract

We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian Continental Ancestry Group / genetics*
  • Butyrophilins
  • Case-Control Studies
  • China
  • Chromosome Mapping
  • Coronary Artery Disease / genetics*
  • European Continental Ancestry Group / genetics
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Guanylate Cyclase / genetics
  • Hedgehog Proteins
  • Humans
  • Linkage Disequilibrium
  • Membrane Glycoproteins / genetics
  • Plasma Membrane Calcium-Transporting ATPases / genetics
  • Polymorphism, Single Nucleotide
  • Proteins / genetics
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Soluble Guanylyl Cyclase

Substances

  • ATP2B1 protein, human
  • BTNL2 protein, human
  • Butyrophilins
  • GUCY1A2 protein, human
  • Hedgehog Proteins
  • Membrane Glycoproteins
  • Proteins
  • Receptors, Cytoplasmic and Nuclear
  • WDR35 protein, human
  • Plasma Membrane Calcium-Transporting ATPases
  • Guanylate Cyclase
  • Soluble Guanylyl Cyclase