On using functional genetics to understand breast cancer biology

Kornelia Polyak

doi:10.1101/cshperspect.a013516

On using functional genetics to understand breast cancer biology

Cold Spring Harb Perspect Biol. 2012 Jul 1;4(7):a013516. doi: 10.1101/cshperspect.a013516.

Author

Kornelia Polyak¹

Affiliation

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA. kornelia_polyak@dfci.harvard.edu

Abstract

Translating functional genomics screens into therapeutic interventions for treating breast cancer has presented challenges. Identifying synthetic lethal interactions in cancer cells using these screens may hold promise.

MeSH terms

Breast Neoplasms / genetics*
Breast Neoplasms / pathology
Female
Genomics*
Humans