p53 and cancer stem cells: the mevalonate connexion

Cell Cycle. 2012 Jul 15;11(14):2583-4. doi: 10.4161/cc.21092. Epub 2012 Jul 15.

Abstract

Comment on: Freed-Pastor WA, et al. Cell 2012; 148:244-58 and Ginestier C, et al. Stem Cells 2012; 1327-37.

Publication types

  • Editorial

MeSH terms

  • Alkyl and Aryl Transferases / antagonists & inhibitors
  • Alkyl and Aryl Transferases / metabolism
  • Animals
  • Cyclin-Dependent Kinase Inhibitor p27 / metabolism
  • Mevalonic Acid / metabolism*
  • Mice
  • Neoplastic Stem Cells / enzymology
  • Neoplastic Stem Cells / metabolism*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*
  • rhoA GTP-Binding Protein / metabolism

Substances

  • Tumor Suppressor Protein p53
  • Cyclin-Dependent Kinase Inhibitor p27
  • Alkyl and Aryl Transferases
  • geranylgeranyltransferase type-I
  • rhoA GTP-Binding Protein
  • Mevalonic Acid