Connective tissue disease: SSc-fibrosis takes flight with Wingless inhibition

Nat Rev Rheumatol. 2012 Aug;8(8):441-2. doi: 10.1038/nrrheum.2012.99. Epub 2012 Jul 3.

Abstract

Recent studies have highlighted a potentially important role for Wnts as profibrotic mediators, and implicated increased Wnt activity in systemic sclerosis and other fibrotic diseases. Strikingly, new data indicates that Wnts have a central role in the profibrotic activity of TGF-β.

Publication types

  • News

MeSH terms

  • Animals
  • Disease Models, Animal
  • Fibrosis / etiology
  • Fibrosis / genetics
  • Fibrosis / metabolism*
  • Fibrosis / prevention & control
  • Humans
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Mice
  • Mice, Transgenic
  • Scleroderma, Systemic / complications
  • Scleroderma, Systemic / genetics
  • Scleroderma, Systemic / metabolism*
  • Transforming Growth Factor beta / metabolism
  • Wnt Proteins / antagonists & inhibitors
  • Wnt Proteins / deficiency
  • Wnt Proteins / metabolism
  • Wnt Signaling Pathway / physiology

Substances

  • Dkk1 protein, mouse
  • Intercellular Signaling Peptides and Proteins
  • Transforming Growth Factor beta
  • Wnt Proteins