Helicobacter Pylori and Infantile Colic

Arch Pediatr Adolesc Med. 2012 Jul 1;166(7):648-50. doi: 10.1001/archpediatrics.2011.1241.

Abstract

Objective: To determine whether Helicobacter pylori is associated with infantile colic.

Design: Case-control study.

Settings: Local tertiary hospital in rural Gizan, Saudi Arabia.

Participants: A total of 55 patients with infantile colic who were 2 weeks to 4 months of age and who fulfilled modified Wessel criteria (ie, crying and fussy behavior) and a total of 30 healthy controls with no history of colic who were matched by country of origin, age, sex, and ethnicity to the 55 colicky infants.

Main outcome measure: Helicobacter pylori infection determined by H pylori stool antigen testing.

Results: Of the 55 patients presenting with infantile colic, 45 (81.8%) tested positive for H pylori ; of the 30 healthy controls, 7 (23.3%) tested positive for H pylori (odds ratio, 15.3 [95% CI, 17.9-29.8]).

Conclusion: H pylori infection is associated with infantile colic and may be a causative factor.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Antigens, Bacterial / analysis
  • Colic / diagnosis
  • Colic / epidemiology
  • Colic / etiology*
  • Colitis / diagnosis
  • Colitis / epidemiology
  • Colitis / etiology*
  • Female
  • Follow-Up Studies
  • Helicobacter Infections / complications*
  • Helicobacter Infections / epidemiology
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / immunology
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Male
  • Odds Ratio
  • Retrospective Studies
  • Risk Factors
  • Saudi Arabia / epidemiology

Substances

  • Antigens, Bacterial