Burden of Clostridium difficile on the healthcare system

Clin Infect Dis. 2012 Aug;55 Suppl 2(Suppl 2):S88-92. doi: 10.1093/cid/cis335.


There are few high-quality studies of the costs of Clostridium difficile infection (CDI), and the majority of studies focus on the costs of CDI in acute-care facilities. Analysis of the best available data, from 2008, indicates that CDI may have resulted in $4.8 billion in excess costs in US acute-care facilities. Other areas of CDI-attributable excess costs that need to be investigated are costs of increased discharges to long-term care facilities, of CDI with onset in long-term care facilities, of recurrent CDI, and of additional adverse events caused by CDI.

Publication types

  • Review

MeSH terms

  • Clostridioides difficile / pathogenicity*
  • Clostridium Infections / economics*
  • Clostridium Infections / epidemiology
  • Clostridium Infections / microbiology
  • Cost of Illness*
  • Delivery of Health Care / economics*
  • Disease Management
  • Hospitalization / economics
  • Humans
  • Long-Term Care / economics
  • Patient Discharge / economics
  • Recurrence
  • Time Factors
  • United States / epidemiology