Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting

J Sci Food Agric. 2013 Feb;93(3):457-62. doi: 10.1002/jsfa.5773. Epub 2012 Jul 2.


Background: Leg swelling is a modern-day affliction of sedentary working women. The aim of this study was to evaluate the effectiveness of the intake of grape seed extract (GSE) on leg swelling in healthy Japanese women while sitting.

Results: Single intake trials and 14 day intake trials were held in a double-blind, placebo-controlled, crossover clinical study. A prolonged sedentary position was maintained for 6 h after GSE or placebo administration. Leg volume distension, increase in body extracellular fluid, and leg water were significantly suppressed in the GSE groups.

Conclusion: The intake of GSE is a contributing factor in the inhibition of leg swelling in healthy women during prolonged sitting.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Body Composition
  • Body Water / physiology
  • Cross-Over Studies
  • Double-Blind Method
  • Edema / etiology
  • Edema / prevention & control*
  • Female
  • Grape Seed Extract / administration & dosage*
  • Humans
  • Leg*
  • Placebos
  • Posture*
  • Proanthocyanidins / administration & dosage*
  • Vitis


  • Grape Seed Extract
  • Grape Seed Proanthocyanidins
  • Placebos
  • Proanthocyanidins