Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum

Bianca Pérez; Cátia Teixeira; Jiri Gut; Philip J Rosenthal; José R B Gomes; Paula Gomes

doi:10.1002/cmdc.201200257

Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum

ChemMedChem. 2012 Sep;7(9):1537-40. doi: 10.1002/cmdc.201200257. Epub 2012 Jun 29.

Authors

Bianca Pérez¹, Cátia Teixeira, Jiri Gut, Philip J Rosenthal, José R B Gomes, Paula Gomes

Affiliation

¹ Centro de Investigação em Química, Departamento de Química e Bioquímic, Faculdade de Ciências da Universidade do Porto, R. do Campo Alegre, 4169-007 Porto, Portugal.

PMID: 22753234
DOI: 10.1002/cmdc.201200257

Abstract

Cinnamic acid derivatives containing a 4-amino-7-chloroquinoline scaffold (blue) and substituted cinnamoyl building blocks (green) linked through an alkylamine chain (red) were found to have potent (11-59 nM) in vitro activities against erythrocytic chloroquine- resistant Plasmodium falciparum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / chemistry*
Antimalarials / pharmacology*
Chloroquine / analogs & derivatives*
Chloroquine / pharmacology*
Cinnamates / chemistry*
Cinnamates / pharmacology*
Drug Resistance
Erythrocytes / parasitology
Humans
Malaria, Falciparum / drug therapy
Plasmodium falciparum / drug effects*

Substances

Antimalarials
Cinnamates
cinnamic acid
Chloroquine