Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?

Oncoimmunology. 2012 Jul 1;1(4):575-577. doi: 10.4161/onci.19401.


We recently described hypoxia as one of the leading mechanism for the recruitment of regulatory T cells (Treg) through CCL28 chemokine in ovarian cancer. Treg promote progression of cancer through tumor-specific immune paralysis but also reprogramming of angiogenesis. We review these mechanisms and discuss the challenges and opportunities for therapy targeting Treg.