Aromatase inhibitors--a viable option for recurrent granulosa cell tumour of ovary: overview and case report

J Pak Med Assoc. 2012 May;62(5):505-7.

Abstract

Granulosa cell tumour of the ovary in adults is a rare tumour of low malignant potential affecting middle aged peri or post menopausal patients. These tumours are often diagnosed at an early stage, due to their hormonally active nature. They, however, have unique distinguishing histologic features and behaviour of frequent and late local or systemic relapses. The diagnosis can be challenging with unusual presentations. There is high association of endometrial carcinoma. Surgery is the mainstay of management in early low risk disease, while radiotherapy and systemic platinum based chemotherapy are employed in higher stage with poor prognostic indices. Survival is good in early stage disease. Recurrent, progressive, and treatment refractory disease is not infrequent and poses management challenge. Endocrine manipulation and hormone treatment are employed in few cases with equivocal results, as reported in literature. We present a case of recurrent and treatment refractory GCT in a postmenopausal patient, managed by aromatase inhibitor Anastrozole with reasonable efficacy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anastrozole
  • Aromatase Inhibitors / therapeutic use*
  • Female
  • Granulosa Cell Tumor / diagnostic imaging
  • Granulosa Cell Tumor / drug therapy*
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / drug therapy*
  • Nitriles / therapeutic use*
  • Ovarian Neoplasms / diagnostic imaging
  • Ovarian Neoplasms / drug therapy*
  • Tomography, X-Ray Computed
  • Triazoles / therapeutic use*

Substances

  • Aromatase Inhibitors
  • Nitriles
  • Triazoles
  • Anastrozole