Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

Rev Soc Bras Med Trop. 2012 Jun;45(3):305-8. doi: 10.1590/s0037-86822012000300005.

Abstract

Introduction: HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection.

Methods: A cross-sectional study was carried out in Salvador, Brazil, between September 2005 and December 2008, involving 50 HTLV-1-infected women from the HTLV Reference Center and 40 uninfected patients from gynecological clinic, both at the Bahiana School of Medicine. HPV infection was assessed using hybrid capture. HTLV-1 proviral load was quantified using real-time polymerase chain reaction (PCR).

Results: The mean age of HTLV-1-infected women (38 ± 10 years) was similar to that of the control group (36 ± 13 years). The prevalence of HPV infection was 44% in the HTLV-1-infected group and 22.5% in uninfected women (p = 0.03). HTLV-1-infected women had lower mean age at onset of sexual life (17 ± 3 years versus 19 ± 3 years; p = 0.03) and greater number of lifetime partners compared with the control group (4 ± 3 versus 2 ± 1; p < 0.01). In the group of HTLV-1-infected patients, there was neither difference in HTLV-1 proviral load between HPV-infected women and the uninfected.

Conclusions: The prevalence of HPV infection was higher in HTLV-1-infected women. Further studies should be performed to evaluate the progression of this co-infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brazil / epidemiology
  • Coinfection / epidemiology*
  • Coinfection / virology
  • Epidemiologic Methods
  • Female
  • HTLV-I Infections / epidemiology*
  • Humans
  • Middle Aged
  • Papillomavirus Infections / epidemiology*
  • Real-Time Polymerase Chain Reaction
  • Uterine Cervical Diseases / epidemiology*
  • Uterine Cervical Diseases / virology
  • Young Adult