Cytokinesis mechanics and mechanosensing

Cytoskeleton (Hoboken). 2012 Oct;69(10):700-9. doi: 10.1002/cm.21045. Epub 2012 Jul 3.


Cytokinesis shape change occurs through the interfacing of three modules, cell mechanics, myosin II-mediated contractile stress generation and sensing, and a control system of regulatory proteins, which together ensure flexibility and robustness. This integrated system then defines the stereotypical shape changes of successful cytokinesis, which occurs under a diversity of mechanical contexts and environmental conditions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Animals
  • Biomechanical Phenomena
  • Cytokinesis*
  • Cytoskeleton / metabolism
  • Humans
  • Mechanotransduction, Cellular*
  • Myosin Type II / metabolism


  • Myosin Type II