Goal directed fluid therapy

Curr Pharm Des. 2012;18(38):6215-24. doi: 10.2174/138161212803832399.


The cornerstone of treating patients with shock remains as it has for decades, intravenous fluids. Surprisingly, dosing intravenous fluid during resuscitation of shock remains largely empirical. Recent data suggests that early aggressive resuscitation of critically ill patients may limit and/or reverse tissue hypoxia, progression to organ failure and improve outcome. However, overzealous fluid resuscitation has been associated with increased complications, increased length of intensive care unit (ICU) and hospital stay and increased mortality. This review focuses on methods to assess fluid responsiveness and the application of these methods for goal directed fluid therapy in critically ill and peri-operative patients.

Publication types

  • Review

MeSH terms

  • Blood Volume Determination
  • Critical Illness
  • Fluid Therapy* / adverse effects
  • Fluid Therapy* / mortality
  • Hemodynamics
  • Humans
  • Intensive Care Units
  • Length of Stay
  • Monitoring, Physiologic
  • Perioperative Care / adverse effects
  • Perioperative Care / methods*
  • Perioperative Care / mortality
  • Respiration, Artificial
  • Shock / diagnosis
  • Shock / mortality
  • Shock / physiopathology
  • Shock / therapy*
  • Time Factors
  • Treatment Outcome