Lowered Serum amyloid-β1-42 Autoantibodies in Individuals With Lifetime Depression

J Alzheimers Dis. 2012;32(1):95-100. doi: 10.3233/JAD-2012-120625.

Abstract

Reduced levels of naturally occurring autoantibodies against amyloid-β (Aβ) have been described in Alzheimer's disease (AD). Lifetime depression doubles the risk of AD, thus these autoantibodies may also be reduced in this group. We measured serum IgG autoantibody titers against Aβ1-42, S100b and α-synuclein in 214 individuals with depression and 419 controls. Titers against Aβ1-42 were lower in individuals with lifetime depression (5544.6 ± 389.3) compared to controls (7208.7 ± 482.4; p = 0.048). Titers against S100b and α-synuclein were comparable between the cohorts. These data suggest an AD-like impairment of the humoral immune response in a relevant proportion of individuals with depression.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amino Acid Sequence
  • Amyloid beta-Peptides / immunology*
  • Autoantibodies / analysis*
  • Biomarkers
  • Cohort Studies
  • Demography
  • Depression / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Nerve Growth Factors / immunology
  • Nerve Growth Factors / metabolism
  • Neuropsychological Tests
  • Peptide Fragments / immunology*
  • Risk Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins / immunology
  • S100 Proteins / metabolism
  • alpha-Synuclein / blood

Substances

  • Amyloid beta-Peptides
  • Autoantibodies
  • Biomarkers
  • Nerve Growth Factors
  • Peptide Fragments
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • S100B protein, human
  • alpha-Synuclein
  • amyloid beta-protein (1-42)