Long-term efficacy of Boswellia serrata in four patients with chronic cluster headache

Cephalalgia. 2012 Jul;32(9):719-22. doi: 10.1177/0333102412451357.


Background: Cluster headache is an extremely severe and debilitating trigemino-autonomic pain syndrome. About 10% of patients with cluster headache manifest a chronic form (CCH).The present case series study aims to evaluate the long-term efficacy of Boswellia serrata (Sallaki H15) on headaches and disturbed sleep in patients with CCH.

Case results: In an open-label study, four patients with CCH and disturbed sleep received oral B. serrata.

Conclusion: The results provide Class IV evidence that oral B. serrata reduces the intensity and frequency of headaches in patients with CCH.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Boswellia / chemistry*
  • Cluster Headache / drug therapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Resins, Plant / administration & dosage*
  • Sleep Wake Disorders / drug therapy
  • Treatment Outcome
  • Triterpenes / administration & dosage*


  • Resins, Plant
  • Triterpenes
  • salai guggal