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. 2012;7(6):e39527.
doi: 10.1371/journal.pone.0039527. Epub 2012 Jun 29.

Neural Network Development in Late Adolescents During Observation of Risk-Taking Action

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Free PMC article

Neural Network Development in Late Adolescents During Observation of Risk-Taking Action

Miyuki Tamura et al. PLoS One. .
Free PMC article

Abstract

Emotional maturity and social awareness are important for adolescents, particularly college students beginning to face the challenges and risks of the adult world. However, there has been relatively little research into personality maturation and psychological development during late adolescence and the neural changes underlying this development. We investigated the correlation between psychological properties (neuroticism, extraversion, anxiety, and depression) and age among late adolescents (n = 25, from 18 years and 1 month to 22 years and 8 months). The results revealed that late adolescents became less neurotic, less anxious, less depressive and more extraverted as they aged. Participants then observed video clips depicting hand movements with and without a risk of harm (risk-taking or safe actions) during functional magnetic resonance imaging (fMRI). The results revealed that risk-taking actions elicited significantly stronger activation in the bilateral inferior parietal lobule, temporal visual regions (superior/middle temporal areas), and parieto-occipital visual areas (cuneus, middle occipital gyri, precuneus). We found positive correlations of age and extraversion with neural activation in the insula, middle temporal gyrus, lingual gyrus, and precuneus. We also found a negative correlation of age and anxiety with activation in the angular gyrus, precentral gyrus, and red nucleus/substantia nigra. Moreover, we found that insula activation mediated the relationship between age and extraversion. Overall, our results indicate that late adolescents become less anxious and more extraverted with age, a process involving functional neural changes in brain networks related to social cognition and emotional processing. The possible neural mechanisms of psychological and social maturation during late adolescence are discussed.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Examples of movies (risk-taking and safe).
Figure 2
Figure 2. Brain images of neural activity in response to the observation of the object-related hand movement task for risk-taking actions vs. safe actions.
Statistical threshold for illustrating the clusters was p<0.001 uncorrected. The bar on the right shows the range of t scores for statistical parametric mapping. Calc. S, calcarine sulcus; FG, fusiform gyrus; FP, frontal pole; MFG, middle frontal gyrus; MTG, middle temporal gyrus; Occ, occipital cortex; SMA, supplementary motor area; SMG, supramarginal gyrus; SPG, superior parietal gyrus.
Figure 3
Figure 3. (A) Scatterplots of associations between insula activity (BA13, peak in MNI space: −40 −10 20) and age for the peak of the clusters surviving conjunction analysis with an independent regression of extraversion.
Left panel: association between age and insula activity (r = 0.60, p<0.01). Right panel: association between extraversion and insula activity (r = 0.61, p<0.01). (B) Brain regions that mediated the relationship between age and extraversion. Parameter estimates (risk-taking > safe contrast) extracted at the region identified by conjunction analyses were independently regressed by age and psychological properties. Mediation tests were based on methods described by Shrout and Bolger (2002) and Baron and Kenny (1986). (a) Regression slope of age predicting neural activity; (b) regression slope of neural activity predicting extraversion, controlling for age; (c) regression slope of age predicting extraversion; (c’) regression slope of age predicting extraversion, controlling for neural activity. Bootstrapping was used to estimate indirect effects (Shrout & Bolger, 2002; see also Preacher & Hayes, 2004). A confidence interval that does not overlap with zero indicates statistically significant mediation. *Indicates significant difference from zero, p<0.05. Coordinates are given in MNI space.

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