Effects of particulate matter on inflammatory markers in the general adult population

Part Fibre Toxicol. 2012 Jul 6;9:24. doi: 10.1186/1743-8977-9-24.

Abstract

Background: Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway.

Methods: We used baseline data from the CoLaus Study including 6183 adult participants residing in Lausanne, Switzerland. We analyzed the association of short-term exposure to PM(10) (on the day of examination visit) with continuous circulating serum levels of high-sensitive C-reactive protein (hs-CRP), interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) by robust linear regressions, controlling for potential confounding factors and assessing effect modification.

Results: In adjusted analyses, for every 10 μg/m(3) elevation in PM(10), IL-1ß increased by 0.034 (95 % confidence interval, 0.007-0.060) pg/mL, IL-6 by 0.036 (0.015-0.057) pg/mL, and TNF-α by 0.024 (0.013-0.035) pg/mL, whereas no significant association was found with hs-CRP levels.

Conclusions: Short-term exposure to PM(10) was positively associated with higher levels of circulating IL-1ß, IL-6 and TNF-α in the adult general population. This positive association suggests a link between air pollution and cardiovascular risk, although further studies are needed to clarify the mechanistic pathway linking PM(10) to cardiovascular risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Air Pollutants / adverse effects*
  • Biomarkers / blood
  • C-Reactive Protein / metabolism*
  • Cardiovascular Diseases
  • Cytokines / blood*
  • Female
  • Humans
  • Inflammation / blood*
  • Inhalation Exposure / adverse effects*
  • Interleukin-1beta / blood
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Particulate Matter / adverse effects*
  • Risk Factors
  • Tumor Necrosis Factor-alpha / blood

Substances

  • Air Pollutants
  • Biomarkers
  • Cytokines
  • IL6 protein, human
  • Interleukin-1beta
  • Interleukin-6
  • Particulate Matter
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein