Isolation and biosynthesis of 3 alpha-hydroxy-3,5-dihydromonacolin L

J Antibiot (Tokyo). 1990 Dec;43(12):1597-600. doi: 10.7164/antibiotics.43.1597.

Abstract

3 alpha-Hydroxy-3,5-dihydromonacolin L acid (acid form), a new compound related to monacolin K (mevinolin), was isolated from the culture broth of a strain of Monascus ruber. The structure of the compound was determined by a combination of physical techniques. 4a,5-Dihydromonacolin L was converted to 3 alpha-hydroxy-3,5-dihydromonacolin L by a cell-free extract of M. ruber in the presence of molecular oxygen. The results demonstrate that the former is the direct precursor in the biosynthesis of the latter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascomycota / metabolism*
  • Chromatography, High Pressure Liquid
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Conformation
  • Molecular Structure
  • Naphthalenes / chemistry
  • Naphthalenes / isolation & purification*
  • Spectrophotometry, Ultraviolet

Substances

  • Naphthalenes
  • 3-hydroxy-3,5-dihydromonacolin L