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Review
. 2012 Jul 6;11(1):9-15.
doi: 10.1016/j.stem.2012.06.012.

Epigenetic Alterations in Human Pluripotent Stem Cells: A Tale of Two Cultures

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Review

Epigenetic Alterations in Human Pluripotent Stem Cells: A Tale of Two Cultures

Anton Wutz. Cell Stem Cell. .
Free article

Abstract

Human somatic cells can be reprogrammed into induced pluripotent stem cells (hiPSCs) with wide lineage differentiation potential in culture. However, reprogramming and long-term culture can also induce abnormalities in these pluripotent cells. This minireview discusses recent studies that have identified changes in imprinted gene expression and erosion of X chromosome inactivation in female hiPSCs and how understanding the sources and consequences of epigenetic variability in hiPSCs will impact disease modeling and clinical application in the future.

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