mRNA translation: regulating an out of soma experience

Curr Opin Cell Biol. 2012 Aug;24(4):554-7. doi: 10.1016/j.ceb.2012.06.005. Epub 2012 Jul 6.

Abstract

The regulation of protein synthesis in discrete cellular subdomains, or local protein synthesis, has important roles in development as well as brain function. This review will discuss some recent findings that shed new light on mRNA translation regulation and how these layers of regulation may work together to elicit tissue specific and spatially restricted gene expression.

Publication types

  • Review

MeSH terms

  • Animals
  • Neurons / cytology
  • Neurons / metabolism
  • Protein Biosynthesis*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Ribosomes / genetics
  • Ribosomes / metabolism
  • Synapses / genetics
  • Synapses / metabolism*
  • Ubiquitin / metabolism

Substances

  • RNA, Messenger
  • Ubiquitin