Spirochetal infection of the central nervous system

Infect Dis Clin North Am. 1990 Dec;4(4):731-46.


Four spirochetal diseases frequently involve the central nervous system: syphilis, leptospirosis, relapsing fever, and Lyme borreliosis. In particular, syphilis and Lyme borreliosis are increasing problems. During the spirochetemic phase there is seeding of the nervous system. After a quiescent latent period, there may be late disease flareups producing a variety of neurologic syndromes. Cerebrospinal fluid examination is very helpful in these infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Central Nervous System Diseases*
  • Humans
  • Leptospirosis*
  • Lyme Disease*
  • Neurosyphilis*
  • Relapsing Fever*