FoxO1 in embryonic development

Transcription. 2012 Sep-Oct;3(5):221-5. doi: 10.4161/trns.21051. Epub 2012 Sep 1.


Establishment of the maternal-fetal circulation during embryonic development is a fundamental process required for effective exchange of nutrients, waste products and signaling factors critical to all subsequent stages of fetal growth and development. Recent work has uncovered a previously unrecognized role of the transcription factor FoxO1 in the orchestration of molecular events underlying establishment of maternal-fetal circulatory interaction. These new data contribute to a larger body of literature implicating this protein in the governance of a wide array of processes during development and beyond.

Keywords: FoxO; allantois; cardiovascular; circulation; development; embryogenesis; maternal-fetal circulation; placenta.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiovascular System / growth & development
  • Embryonic Development / physiology*
  • Female
  • Maternal-Fetal Exchange
  • Placentation
  • Pregnancy
  • RNA Splicing Factors
  • RNA-Binding Proteins / physiology*


  • RNA Splicing Factors
  • RNA-Binding Proteins
  • Rbfox1 protein, mouse