Mesenchymal stem cells: a potential targeted-delivery vehicle for anti-cancer drug, loaded nanoparticles

Nanomedicine. 2013 Feb;9(2):174-84. doi: 10.1016/j.nano.2012.06.003. Epub 2012 Jul 5.


The targeted delivery of anticancer agents is a promising field in anticancer therapy. Mesenchymal stem cells (MSCs) have inherent tumor-tropic and migratory properties, which allow them to serve as vehicles for targeted drug delivery systems for isolated tumors and metastatic diseases. MSCs have been successfully studied and discussed as a vehicle for cancer gene therapy. However, MSCs have not yet been discussed adequately as a potential vehicle for traditional anticancer drugs. In this review, we will examine the potential of MSCs as a targeted-delivery vehicle for anticancer drug-loaded nanoparticles (NPs), summarize various challenges, and discuss possible solutions for these challenges.

From the clinical editor: In this review, the feasibility of mesenchymal stem cell-based targeted delivery of anticancer agents is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Drug Delivery Systems / methods*
  • Humans
  • Mesenchymal Stem Cells / cytology*
  • Nanoparticles / analysis*
  • Neoplasms / drug therapy*


  • Antineoplastic Agents