Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Aug;14(8):882-90.
doi: 10.1038/ncb2535. Epub 2012 Jul 8.

Sox10 Promotes the Formation and Maintenance of Giant Congenital Naevi and Melanoma

Affiliations

Sox10 Promotes the Formation and Maintenance of Giant Congenital Naevi and Melanoma

Olga Shakhova et al. Nat Cell Biol. .

Abstract

Giant congenital naevi are pigmented childhood lesions that frequently lead to melanoma, the most aggressive skin cancer. The mechanisms underlying this malignancy are largely unknown, and there are no effective therapies. Here we describe a mouse model for giant congenital naevi and show that naevi and melanoma prominently express Sox10, a transcription factor crucial for the formation of melanocytes from the neural crest. Strikingly, Sox10 haploinsufficiency counteracts Nras(Q61K)-driven congenital naevus and melanoma formation without affecting the physiological functions of neural crest derivatives in the skin. Moreover, Sox10 is also crucial for the maintenance of neoplastic cells in vivo. In human patients, virtually all congenital naevi and melanomas are SOX10 positive. Furthermore, SOX10 silencing in human melanoma cells suppresses neural crest stem cell properties, counteracts proliferation and cell survival, and completely abolishes in vivo tumour formation. Thus, SOX10 represents a promising target for the treatment of congenital naevi and melanoma in human patients.

Similar articles

See all similar articles

Cited by 82 articles

See all "Cited by" articles

References

    1. Nat Genet. 1998 Feb;18(2):171-3 - PubMed
    1. Expert Rev Dermatol. 2009 Apr 1;4(2):131 - PubMed
    1. Pigment Cell Melanoma Res. 2010 Dec;23(6):729-35 - PubMed
    1. Am J Surg Pathol. 2008 Sep;32(9):1291-8 - PubMed
    1. Nature. 2002 Apr 25;416(6883):854-60 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback