Oncology in vivo data integration for hypothesis generation

J Integr Bioinform. 2012 Jul 9;9(2):193. doi: 10.2390/biecoll-jib-2012-193.

Abstract

AstraZeneca’s Oncology in vivo data integration platform brings multidimensional data from animal model efficacy, pharmacokinetic and pharmacodynamic data to animal model profiling data and public in vivo studies. Using this platform, scientists can cluster model efficacy and model profiling data together, quickly identify responder profiles and correlate molecular characteristics to pharmacological response. Through meta-analysis, scientists can compare pharmacology between single and combination treatments, between different drug scheduling and administration routes.

MeSH terms

  • Animals
  • Data Interpretation, Statistical
  • Databases, Factual*
  • Drug Discovery
  • Drug Industry
  • Internet
  • Medical Oncology
  • Neoplasms, Experimental / drug therapy*
  • Pharmacokinetics
  • Pharmacology