Patient-specific factors relating to medication adherence in a post-percutaneous coronary intervention cohort

Int J Pharm Pract. 2012 Aug;20(4):226-37. doi: 10.1111/j.2042-7174.2011.00185.x. Epub 2012 Feb 3.


Objective: To explore the association between medication adherence and qualitatively characterised patient-specific themes relating to medication adherence in patients following percutaneous coronary intervention (PCI).

Methods: Data-collection questionnaires and qualitative topic guides were piloted in two patients. A validated questionnaire generated an adherence score for a convenience sample of 20 patients within 7 days of PCI. Semi-structured qualitative interviews were subsequently carried out with all patients to explore patient-specific themes relating to measured medication adherence.

Key findings: Fourteen out of 20 patients (70%) had scores indicative of good adherence. Key factors associated with good adherence included having a good relationship with the doctor, having an understanding of the condition, knowledge of the indications and consequences of non-adherence, perceived health benefits and medications eliciting tangible symptom control. There were misconceptions of concern regarding adverse drug reactions and the importance of aspirin, both of which had a negative effect on adherence. The role of the community pharmacist was sometimes, although not always, misunderstood.

Conclusion: This study suggests there is an association between patients' beliefs, knowledge, understanding and misconceptions about medication and their adherence in a post-PCI cohort. To optimise medication adherence it is vital for prescribers to remain patient-focused and cognisant of patient-specific themes relating to medication adherence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary / methods*
  • Aspirin / therapeutic use
  • Community Pharmacy Services / organization & administration
  • Female
  • Health Knowledge, Attitudes, Practice*
  • Humans
  • Male
  • Medication Adherence*
  • Middle Aged
  • Pharmacists / organization & administration
  • Physician-Patient Relations
  • Pilot Projects
  • Platelet Aggregation Inhibitors / therapeutic use
  • Professional Role
  • Surveys and Questionnaires


  • Platelet Aggregation Inhibitors
  • Aspirin