Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects

Ann Nutr Metab. 2012;61(1):15-24. doi: 10.1159/000338634. Epub 2012 Jul 5.


Background: The preventive effect of resveratrol (RES) on the development of human diseases has been verified by numerous epidemiological studies. Resveratrol triphosphate (RTP) is a stable derivative of RES in which phosphate groups protect the phenolic groups.

Aims: This study compared the effect of RTP on biochemical and molecular markers of oxidative stress to equimolar doses (0.66 mmol) of RES and catechin-rich grape seed extract (CGSE) in a model of oxidative and metabolic stress associated with obesity in humans.

Methods: Thirty-two obese subjects (BMI between 30 and 40) were enrolled. They all received 1 capsule of placebo/day for 28 days before being randomly devised into three arms receiving 1 capsule/day of RES, CGSE, or RTP during the following consecutive 28 days. Blood samples were collected at baseline, after the end of placebo intake, and after the end of the investigational product intake. Biochemical parameters of oxidative stress and blood expression of 200 redox-related genes were determined at each time point.

Results: RTP and CGSE showed better antioxidant activities compared to RES and induced important modulations of gene expression.

Conclusion: The results suggest that RTP and CGSE could contribute to a significant reduction of oxidative stress in obese subjects.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antioxidants / administration & dosage
  • Biomarkers / blood
  • Catechin / administration & dosage*
  • Dietary Supplements
  • Female
  • Gene Expression
  • Grape Seed Extract / pharmacology*
  • Humans
  • Male
  • Microarray Analysis
  • Middle Aged
  • Obesity / blood
  • Obesity / physiopathology*
  • Organophosphates / administration & dosage*
  • Oxidative Stress / drug effects*
  • Resveratrol
  • Stilbenes / administration & dosage*


  • Antioxidants
  • Biomarkers
  • Grape Seed Extract
  • Organophosphates
  • Stilbenes
  • resveratrol triphosphate
  • Catechin
  • Resveratrol