An inhibitor of glutathione S-transferase omega 1 that selectively targets apoptotic cells

Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8365-8. doi: 10.1002/anie.201203730. Epub 2012 Jul 6.

Authors

Nicholas J Pace¹, Daniel R Pimental, Eranthie Weerapana

Affiliation

¹ Department of Chemistry, Merkert Chemistry Center, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.

PMID: 22777685
DOI: 10.1002/anie.201203730

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Glutathione Transferase / antagonists & inhibitors*
Glutathione Transferase / metabolism
HeLa Cells
Humans
Microscopy, Fluorescence
Molecular Structure
Neoplasms / drug therapy
Neoplasms / enzymology*
Neoplasms / pathology*
Peptides / chemical synthesis
Peptides / chemistry
Peptides / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Enzyme Inhibitors
Peptides
GSTO1 protein, human
Glutathione Transferase