Synthesis of 1-octanol and 1,1-dioctyl ether from biomass-derived platform chemicals

Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8615-9. doi: 10.1002/anie.201203669. Epub 2012 Jul 6.


The happy medium: A new catalytic pathway for the synthesis of the linear primary C(8) alcohol products 1-octanol and dioctyl ether from furfural and acetone has been developed using retrosynthetic analysis. This opens a general strategy for the synthesis of medium-chain-length alcohols from carbohydrate feedstock.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Octanol / chemical synthesis*
  • 1-Octanol / chemistry
  • Biomass*
  • Catalysis
  • Ethers / chemical synthesis*
  • Ethers / chemistry


  • Ethers
  • 1-Octanol