Glycogenic acanthosis presenting as leukoplakia on the tongue

BMJ Case Rep. 2010 Oct 6;2010:bcr0120102634. doi: 10.1136/bcr.01.2010.2634.


This report describes a rare case of glycogenic acanthosis (GA) located on the tongue of a 72-year-old man. The patient presented with a white plaque that had been on the right side of the tongue for 5 years. Histologically, the lesion was characterised by thickened squamous epithelium with abundant intracellular glycogen deposits. No epithelial dysplasia was noted. This is the first report of GA involving the tongue. This benign condition should be added to the large number of lesions responsible for leukoplakia in this anatomical location.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy, Needle
  • Diagnosis, Differential
  • Glycogen / metabolism*
  • Humans
  • Immunohistochemistry
  • Keratosis / diagnosis
  • Keratosis / pathology*
  • Leukoplakia, Oral / diagnosis
  • Leukoplakia, Oral / pathology*
  • Male
  • Precancerous Conditions / pathology*
  • Tongue Diseases / diagnosis
  • Tongue Diseases / pathology*


  • Glycogen