Eukaryotic protein elongation factors

Trends Biochem Sci. 1990 Nov;15(11):420-4. doi: 10.1016/0968-0004(90)90279-k.


In eukaryotes, peptide chain elongation is mediated by elongation factors EF-1 and EF-2. EF-1 is composed of a nucleotide-binding protein EF-1 alpha, and a nucleotide exchange protein complex, EF-1 beta gamma, while EF-2 catalyses the translocation of peptidyl-tRNA on the ribosome. Elongation factors are highly conserved among different species and may be involved in functions other than protein synthesis, such as organization of the mitotic apparatus, signal transduction, developmental regulation, ageing and transformation. Yeast contains a third factor, EF-3, whose structure and function is not yet well understood.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / physiology*
  • Humans
  • Peptide Elongation Factors / physiology*
  • Protein Conformation
  • Protein Processing, Post-Translational
  • Saccharomyces cerevisiae


  • Peptide Elongation Factors