Therapeutic targets in cancer cell metabolism and autophagy

Nat Biotechnol. 2012 Jul 10;30(7):671-8. doi: 10.1038/nbt.2285.

Abstract

The metabolism of cancer cells is reprogrammed both by oncogene signaling and by dysregulation of metabolic enzymes. The resulting altered metabolism supports cellular proliferation and survival but leaves cancer cells dependent on a continuous supply of nutrients. Thus, many metabolic enzymes have become targets for new cancer therapies. Recently, two processes—expression of specific isoforms of metabolic enzymes and autophagy—have been shown to be crucial for the adaptation of tumor cells to changes in nutrient availability. An increasing number of approved and experimental therapeutics target these two processes. A better understanding of the molecular basis of cancer-associated metabolic changes may lead to improved cancer therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acids / metabolism
  • Autophagy*
  • Cell Proliferation
  • Enzymes* / genetics
  • Enzymes* / metabolism
  • Glucose / metabolism
  • Humans
  • Metabolic Networks and Pathways / genetics*
  • Molecular Targeted Therapy*
  • Neoplasms* / enzymology
  • Neoplasms* / pathology
  • Neoplasms* / therapy
  • Nucleic Acids / metabolism

Substances

  • Amino Acids
  • Enzymes
  • Nucleic Acids
  • Glucose