Ethyl cyanoacetate: a new cyanating agent for the palladium-catalyzed cyanation of aryl halides

Org Lett. 2012 Jul 20;14(14):3644-7. doi: 10.1021/ol3014914. Epub 2012 Jul 11.

Abstract

A new Pd-catalyzed cyanation reaction has been discovered using ethyl cyanoacetate as the cyanating reagent. A variety of electron-rich and electron-deficient aryl halides were efficiently converted into their corresponding nitriles in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / chemistry*
  • Catalysis
  • Hydrocarbons, Halogenated / chemistry*
  • Molecular Structure
  • Palladium / chemistry*

Substances

  • Acetates
  • Hydrocarbons, Halogenated
  • Palladium
  • ethyl cyanoacetate