ABO-incompatible kidney transplantation

Curr Opin Organ Transplant. 2012 Aug;17(4):376-85. doi: 10.1097/MOT.0b013e328355f013.

Abstract

Purpose of review: A dramatic shortage of available organs around the world encouraged attempts to cross previously forbidden immunological boundaries in kidney transplantation. This review focuses on the recent results of ABO-incompatible kidney transplantation.

Recent findings: The outcome of ABO-incompatible kidney transplantation in terms of patient and graft survival is comparable to ABO-compatible transplantation for adult and pediatric recipients. Splenectomy has been replaced by the B-cell-depleting agent rituximab to avoid isoagglutinin titer rebound, prevent antibody-mediated rejection, and improve graft survival. However, the risk for infections may be increased and warrants caution. Corticosteroids remain a necessary component of any ABO-incompatible protocol; early as well as late steroid withdrawal may bear an enhanced risk for acute rejection and should only be performed with careful follow-up including protocol biopsies. The few studies that have long-term outcomes using protocol biopsies have characterized a state of accommodation by up-regulation of complement inhibitors, down-regulation of A/B antigens, and establishment of endothelial chimerism over time.

Summary: The experience accumulated around the world indicates that ABO-incompatible kidney transplantation is well tolerated and effective in adults and in children, and it represents an important step forward in expanding the living donor pool. Further understanding of ABO-incompatible graft accommodation may have broader implication also for human leukocyte antigen-sensitized allograft recipients.

Publication types

  • Review

MeSH terms

  • ABO Blood-Group System / immunology*
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Desensitization, Immunologic
  • Graft Rejection / immunology
  • Graft Rejection / therapy*
  • Graft Survival / immunology
  • Humans
  • Immunologic Factors / therapeutic use
  • Kidney Transplantation / immunology*
  • Rituximab
  • Transplantation Tolerance / immunology
  • Treatment Outcome

Substances

  • ABO Blood-Group System
  • Antibodies, Monoclonal, Murine-Derived
  • Immunologic Factors
  • Rituximab