Growth factor-induced gene expression: the ups and downs of c-fos regulation

New Biol. 1990 Sep;2(9):751-8.


Many growth factor-inducible immediate-early genes, including c-fos, encode transcription factors that are believed to propagate the mitogenic signal by activating a program of gene expression critical for cell proliferation. This review summarizes work aimed at elucidating the molecular mechanisms by which a growth factor-induced signal effects a change in gene expression. In the case of c-fos, both the activation and repression of transcription are mediated by the serum response element, a dyad symmetrical sequence found upstream of the c-fos gene. This element binds a complex of proteins, a component(s) of which may be the target of the growth factor-induced signal. Recent progress made towards understanding the roles of these factors in the regulation of c-fos transcription will be described.

Publication types

  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Binding Sites
  • Cell Division / drug effects
  • Cell Division / genetics
  • DNA / genetics
  • DNA / metabolism
  • Gene Expression Regulation / drug effects
  • Growth Substances / metabolism
  • Growth Substances / pharmacology*
  • Molecular Sequence Data
  • Nuclear Proteins / metabolism
  • Nuclear Proteins / pharmacology
  • Proto-Oncogenes / drug effects*
  • Serum Response Factor
  • Transcription, Genetic / drug effects


  • Growth Substances
  • Nuclear Proteins
  • Serum Response Factor
  • DNA