Surfactant replacement in spontaneously breathing babies with hyaline membrane disease--a pilot study

Biol Neonate. 1990;58(3):121-6. doi: 10.1159/000243250.


In a neonatal unit which, at that time, had no facilities for artificial ventilation, 14 newborn infants with birth weight greater than or equal to 1,500 g fulfilling the diagnostic criteria for severe hyaline membrane disease (HMD) were treated by tracheal instillation of bovine surfactant (200 mg/kg). Twelve of these babies showed increased transcutaneous PO2/FiO2 ratio within 2 min, the average therapeutic response being sustained for at least 72 h. One of the two babies who did not respond to treatment was later diagnosed as a case of group B streptococcal pneumonia. One baby with favorable initial response died from sepsis at the age of 7 days; the other patients survived without sequelae. We conclude that treatment with exogenous surfactant might be considered as an alternative to ventilator treatment in babies with severe HMD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Heart Murmurs / complications
  • Humans
  • Hyaline Membrane Disease / complications
  • Hyaline Membrane Disease / physiopathology
  • Hyaline Membrane Disease / therapy*
  • Infant, Newborn
  • Pilot Projects
  • Pneumonia, Viral / physiopathology
  • Pneumonia, Viral / therapy
  • Pulmonary Surfactants / therapeutic use*
  • Respiration*
  • Streptococcal Infections / physiopathology
  • Streptococcal Infections / therapy


  • Pulmonary Surfactants