Association between neutrophil to lymphocyte ratio and severity of coronary artery disease

Clin Appl Thromb Hemost. 2014 Jan;20(1):50-4. doi: 10.1177/1076029612452116. Epub 2012 Jul 11.


The aim of this study is to investigate the association between neutrophil to lymphocyte ratio (NLR) and severity of coronary atherosclerosis. A total of 172 patients undergoing coronary angiography were included in the study. Control group consisted of patients with normal coronary arteries. Patients with coronary stenosis were divided into 2 groups by use of Gensini scores. The NLR was higher in severe atherosclerosis group compared with mild atherosclerosis and control groups (P < .001). In correlation analysis, NLR showed significant correlation with Gensini score. A cutoff value of 2.5 for NLR predicted severe atherosclerosis with a sensitivity and specificity of 62% and 69%, respectively. After multivariate analysis, high levels of NLR were independent predictors of severe atherosclerosis together with glucose and high-density lipoprotein. Our study suggests that the NLR is a predictor of severe atherosclerosis that may be useful for cardiac risk stratification in patients with coronary artery disease.

Keywords: Gensini score; coronary artery disease; neutrophil to lymphocyte ratio.

MeSH terms

  • Atherosclerosis / blood*
  • Coronary Artery Disease / blood*
  • Female
  • Humans
  • Lymphocytes / pathology*
  • Male
  • Middle Aged
  • Neutrophils / pathology*
  • Risk Factors
  • Severity of Illness Index