Suppressive effect on food intake of a potato extract (Potein®) involving cholecystokinin release in rats

Biosci Biotechnol Biochem. 2012;76(6):1104-9. doi: 10.1271/bbb.110936. Epub 2012 Jun 7.


We have recently reported that oral gavage of a potato extract (Potein®) suppressed the food intake in rats. The satiating effect of the potato extract was compared in the present study to other protein sources, and the involvement of endogenous cholecystokinin (CCK) secretion was examined. Food consumption was measured in 18-h fasted rats after oral gavage of the potato extract or other protein sources. The CCK-releasing activity of the potato extract was then examined in anesthetized rats with a portal cannula. Oral gavage of the potato extract reduced the food intake in the rats, the effect being greater than with casein and a soybean β-conglycinin hydrolysate. The suppressive effect on appetite of the potato extract was attenuated by treating with a CCK-receptor antagonist (devazepide). The portal CCK concentration was increased after a duodenal administration of the potato extract to anesthetized rats. These results indicate that the potato extract suppressed the food intake in rats through CCK secretion.

MeSH terms

  • Administration, Oral
  • Animals
  • Antigens, Plant / pharmacology
  • Appetite / drug effects*
  • Appetite / physiology
  • Caseins / pharmacology
  • Cholecystokinin / biosynthesis
  • Cholecystokinin / metabolism*
  • Devazepide / pharmacology
  • Duodenum / drug effects
  • Duodenum / physiology
  • Eating / drug effects*
  • Eating / physiology
  • Fasting
  • Globulins / pharmacology
  • Hormone Antagonists / pharmacology
  • Male
  • Plant Extracts / administration & dosage*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cholecystokinin / antagonists & inhibitors
  • Receptors, Cholecystokinin / metabolism
  • Satiation / drug effects
  • Satiation / physiology
  • Seed Storage Proteins / pharmacology
  • Solanum tuberosum / chemistry*
  • Soybean Proteins / pharmacology


  • Antigens, Plant
  • Caseins
  • Globulins
  • Hormone Antagonists
  • Plant Extracts
  • Receptors, Cholecystokinin
  • Seed Storage Proteins
  • Soybean Proteins
  • beta-conglycinin protein, Glycine max
  • Cholecystokinin
  • Devazepide